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KMID : 0363220120500121017
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Korean Journal of Dermatology
2012 Volume.50 No. 12 p.1017 ~ p.1026
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The Efficacy of the Moisturizer APDDR-1001 for Post-laser Wound Care
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Kim Myoung-Shin
Haw Sik
Lee Hyung-Min
Kim Jeong-Hwan
Jeong Yeon-Su
Shin Hong-Ju
Won Chong-Hyun
Chang Sung-Eun
Lee Mi-Woo
Choi Jee-Ho
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Abstract
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Background: Because cosmetic laser treatments are getting popular, post-laser wound care becomes more important.Currently, topical moisturizers are reported to be sufficient to accelerate re-epithelialization and reduce downtime inpost-laser wound care.Objective: This study was performed to evaluate the effects of the moisturizer APDDR-1001 for post-laser woundcare, after ablative fractional laser on the face.Methods: In this double-blind, split-face study, 41 patients with photo-aged face received ablative fractional laser.They were divided into two groups, APDDR-1001 and vehicle (group 1) or control moisturizer (group 2), whichwere applied to the opposite sides of the face for 1 week after the laser treatment. The treatment efficacy wasevaluated by the transepidermal water loss (TEWL), erythema index, investigator`s assessment for recovery inerythema and overall improvement of the wound. Subjects ranked irritating symptoms and overall satisfaction ratingsin the overall improvement.Results: APDDR-1001 was well-tolerated and showed improvement in the erythema index and TEWL during the 7days of treatment. In group 2, improvement in erythema graded by investigators was significantly higher forAPDDR-1001 on day 3 (p＜0.05). The overall improvement of wound ranked by investigators was significantlyhigher for APDDR-1001, compared with the controls in both groups. Subjective assessment demonstratedsignificantly less erythema (p=0.043), edema (p=0.041) and overall satisfaction ratings in the overall improvement (p＜0.048) with APDDR-1001; however, no differences were detected in pain and edema between APDDR-1001 andvehicle (group 1). In group 2, subjects ranked ``much or very much improved`` in 75 % of APDDR-1001 side and55% of control moisturizer side. No significant differences in erythema, edema, pain and itching were reportedbetween APDDR-1001 and control moisturizer in group 2.Conclusion: The moisturizer APDDR-1001 demonstrated effective improvements in wound healing and subjectivesymptoms after ablative fractional laser therapy.
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KEYWORD
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Fractional Laser, Moisturizer, Wound care, Wound healing
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